Regulating the immune response
The immune response can be described as a series of changes in gene expression that occur across tissues. The overarching goal of the lab is to build a gene regulatory network (GRN) model that describes the system-wide immune response in the sea urchin larva. Sea urchin embryos are the pioneering model system in regulatory biology. We have adapted the experimental techniques originally optimized for disentangling developmental GRNs (e.g., transgenesis and perturbation strategies) to assemble the networks that control the larval response to pathogenic bacteria.